目的:研究附桂干姜汤对正常动物机体状态的影响。方法:24只雄性SD大鼠分为空白对照组,热性中药组(附桂干姜汤组灌胃附子、干姜、肉桂煎液,剂量相当于8g生药/只/天),观察大鼠宏观表现;放射免疫法检测血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、反三碘甲状腺原氨酸(r T3)、皮质酮/肾上腺酮(CORT)、环磷酸腺苷(c AMP)、环磷酸鸟苷(c GMP);紫外分光光度法测17-羟皮质类固醇(17-OHCS)、血糖(GLU)、甘油三脂(TG)、总胆固醇(TC)、总蛋白(TP)、白蛋白(ALB)、尿酸(UA)谷丙转氨酶(GPT)、谷草转氨酶(GOT)、尿素氮(BUN)、肌苷(CRE)、免疫球蛋白M(Ig M)、免疫球蛋白G(Ig G)、补体C3、补体C4。结果:与空白对照组比较,附桂干姜汤8g生药/只作用于正常大鼠,出现耸毛、烦躁的现象,T4、r T3、17-ohcs、cort含量有升高趋势,Ig M、C4、c AMP、c AMP/c GMP值明显升高;结论:附桂干姜汤作用于正常机体,引起甲状腺、肾上腺皮质功能亢进,类似于临床虚热状态,体现出热性类中药温热燥烈易耗阴动火的药性特点。 Objective: To study the effect of Gurgan Ginger Decoction on the normal animal body condition. Methods: Twenty-four male Sprague-Dawley rats were divided into blank control group, hot herbal group (treated with Gui Ginger Decoction group, aconite, ginger and cinnamon decoction, the dosage was equivalent to 8g crude drug / only / day) The radioimmunoassay was used to detect serum T3, T4, rT3, CORT and cAMP c AMP, cGMP, 17-OHCS, GLU, TG, TC and total protein were detected by ultraviolet spectrophotometry TP, ALB, UA GPT, GOT, BUN, CRE, Ig M, immunoglobulin G (Ig G), complement C3, complement C4. Results: Compared with the blank control group, 8g crude drug of Gusui Ganjiang Decoction / only acting on normal rats, the phenomenon of hair-raising and irritation appeared, the contents of T4, rT3,17-ohcs and cort increased, IgM, C4, c AMP, c AMP / c GMP values ​​were significantly increased; Conclusion: Gui Ginger Decoction role in the normal body, causing thyroid, adrenal hyperfunction, similar to clinical hypothermia, reflecting the heat of traditional Chinese medicine warming Drying strong consumption of Yaohuo the characteristics of medicine.