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本文对23例初发Ⅱ型糖尿病(NIDDM)病人进行口服降糖药吡磺环已脲(glipizide)治疗前后的血小板聚集、第Ⅷ因子相关抗原(ⅧR:Ag)和纤维蛋白原进行动态研究。结果表明:NIDDM病人在临床未发现微血管病变时已有血小板聚集率升高,血小板聚集率与空腹血糖、糖化血红蛋白A_1(GHbA_1)无关,与ⅧR:Ag呈明显正相关。glipizide治疗后血小板聚集率明显下降,提示血小板功能异常可能参与NIDDM微血管病变的发生;内皮损害会加剧血小板聚集功能,glipizide对抑制血小板聚集功能有一定作用。
In this paper, 23 patients with newly diagnosed type 2 diabetes mellitus (NIDDM) were treated with oral hypoglycemic agents glipizide before and after glipizide platelet aggregation, Ⅷ R factor related antigen (Ⅷ R: Ag) and fibrinogen dynamic study. The results showed that in patients with NIDDM, there was already an increase in platelet aggregation in the absence of clinical microvascular lesions. The platelet aggregation rate was not related to fasting plasma glucose and HbA1 (GHbA_1), but positively correlated with ⅧR: Ag. glipizide significantly decreased platelet aggregation after treatment, suggesting that abnormal platelet function may be involved in the occurrence of NIDDM microvascular disease; endothelial damage may increase platelet aggregation, glipizide inhibition of platelet aggregation function to a certain extent.