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[目的]探讨原发性肝癌介入治疗前后凝血及纤溶功能的变化。[方法]选取2007年1月～2009年1月来本院就诊并进行介入治疗的92例原发性肝癌患者作为观察组,正常对照组60例,对比分析两组各项指标。采用ELISA法检测P-选择素、尿激酶型纤溶酶原激活物(uPA)、血管性血友病因子(vWF),采用发色底物法检测纤溶酶原激活物抑制物(PAI),采用光散射比浊法检测凝血酶时间(TT)、活化的部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、凝血因子Ⅶ(FⅦ)、Ⅷ(FⅧ)、Ⅹ(FⅩ)及纤维蛋白原含量(Fg)。[结果]观察组介入治疗后,与治疗前相比,PT、APTT、Ps、VWF和uPA都低于治疗前(P﹤0.05);FⅦ、FⅧ高于治疗前(P﹤0.05)。与对照组相比,PT、APTT、TT、Ps、VWF和uPA都高于对照组(P﹤0.05);Fg、FⅦ、FⅧ和FⅩ都低于对照组(P﹤0.05)。[结论]介入治疗能够减轻原发性肝癌患者的凝血和纤溶功能亢进,但不能恢复正常。
[Objective] To investigate the changes of coagulation and fibrinolysis in patients with primary liver cancer before and after interventional therapy. [Methods] A total of 92 primary hepatocellular carcinoma patients treated in our hospital from January 2007 to January 2009 were selected as observation group and 60 normal control group. P-selectin, uPA and vWF were detected by ELISA, and plasminogen activator inhibitor (PAI) (TT), activated partial thromboplastin time (APTT), plasma prothrombin time (PT), coagulation factor VII (FⅦ), Ⅷ (FⅧ), Ⅹ (F Ⅹ ) And fibrinogen content (Fg). [Results] After interventional treatment, PT, APTT, Ps, VWF and uPA in observation group were lower than those before treatment (P <0.05); FⅦ and FⅧ were higher than those before treatment (P <0.05). Compared with the control group, the levels of PT, APTT, TT, Ps, VWF and uPA in the control group were significantly higher than those in the control group (P <0.05). The levels of Fg, FⅦ, FⅧ and Fx in the control group were lower than those in the control group (P <0.05). [Conclusion] Interventional therapy can reduce the coagulation and fibrinolytic activity in patients with primary liver cancer, but can not return to normal.