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AIM:To investigate the effects of chronic supplementation with l-carnitine (LCT) on hepatic catabolism of l-alanine. METHODS: Two groups of male adult Wistar rats were used: 1) supplemented with LCT (1.2 mmol·kg-1·d-1) dissolved in the drinking water (LCT group) and 2) control group (COG) without LCT supplementation . After one week of LCT supplementation livers from 24 h-fasted rats were perfused in situ and the production of glucose, urea, pyruvate, and l-lactate from l-alanine (5 mmol/L) were measured. RESULTS: LCT decreased the production of glucose and urea from l-alanine. In agreement, pyruvate and l-lactate production from l-alanine were decreased. However, the supplementation with LCT did not show any significant effect on hepatic glucose production from pyruvate (5 mmol/L) and l-lactate (2 mmol/L). CONCLUSION: LCT supplementation decreased the conversion of l-alanine to pyruvate. However the ability of the liver to convert pyruvate to glucose was not affected by LCT treatment.
AIM: To investigate the effects of chronic supplementation with l-carnitine (LCT) on hepatic catabolism of l-alanine. METHODS: Two groups of male adult Wistar rats were used: 1) supplemented with LCT (1.2 mmol · kg -1 · d -1) dissolved in the drinking water (LCT group) and 2) control group (COG) without LCT supplementation. After one week of LCT supplementation livers from 24 h-fasted rats were perfused in situ and the production of glucose, urea, pyruvate RESULTS: LCT decreased the production of glucose and urea from l-alanine. In agreement, pyruvate and l-lactate production from l-alanine were decreased. , the supplementation with LCT did not show any significant effect on hepatic glucose production from pyruvate (5 mmol / L) and l-lactate (2 mmol / L). CONCLUSION: LCT supplementation decreased the conversion of l-alanine to pyruvate. However the ability of the liver to convert pyruvate to glucose was not affected by LCT treatmen t.