介绍了一种能方便、准确测定酒精中毒小鼠血液中ＳＯＤ酶活的方法，采用二硫苏糖醇（ＤＴＴ）为终止剂的邻苯三酚自氧化法反应体系条件ｐＨ＝８２０±００１，反应温度３０±０１℃，邻苯三酚浓度００９８ｍｍｏｌ／Ｌ，ＤＴＴ浓度２７３μｍｏｌ／Ｌ，红细胞ＳＯＤ粗提液加样量０１２５ｍＬ，测试波长４２０ｎｍ本法重复性好，ＣＶ＝２８２％（ｎ＝６）应用本法测得鼠血中ＳＯＤ酶活变化趋势与鼠血中乙醇浓度和翻正反射消失情况有相关性，表明本法可用于酒精中毒的防治研究 A convenient and accurate method for the determination of SOD activity in the blood of alcohol-poisoned mice was introduced. The conditions of pyrogallol autoxidation reaction with dithiothreitol (DTT) as the final pH = 820 ± 001, reaction temperature 30 ± 01 ℃, pyrogallol concentration 0098mmol / L, DTT concentration 273μmol / L, erythrocyte SOD crude extract sample volume 0  125mL, the test wavelength 420nm  Law repeatability, CV = 2  82% (n = 6)  Determination of SOD activity in rat blood using this method trends and mouse blood ethanol concentration and the disappearance of reflex correlativity, indicating that this method is available Prevention and treatment of alcoholism 