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实验用Wistar大鼠40只,分对照、关节炎、电针、纳洛酮阻断四组。以减毒结核菌在后足踝、蹠关节形成实验性关节炎,作为慢性疼痛模型。测定蹠围、炎症局部皮温和痛反应阈。电针两侧环跳穴,引针20分。每日一次、五日为一疗程、间隙三天,共做三个疗程。甲啡肽(MEK)含量以放射免疫法测定。结果发现,电针对大鼠实验性关节炎无明显长时间的止痛作用,对炎症也无影响。正常大鼠下丘脑,垂体MEK含量分别为250.43±40.40pg/mg与297.81±39.00pg/mg。关节炎组分别为160.54±32.25与228.85±31.18pg/mg,明显低于正常(P<0.01)。电针组MEK含量分别为251.00±38.46与286.36±41.92pg/mg。可见,电针能使关节炎大鼠大丘脑和垂体的MEK含量提高(P<0.01)。
40 Wistar rats were used in the experiment and divided into four groups: control, arthritis, electroacupuncture, and naloxone. The attenuated Mycobacterium tuberculosis developed experimental arthritis in hindpaw and ankle joints as a chronic pain model. Peripheral skin temperature and pain reaction threshold were measured. Acupuncture points on both sides of the electroacupuncture were punctured and 20 points were introduced. Once a day, five days for a course of treatment, clearance for three days, a total of three courses. Metocine (MEK) content was determined by radioimmunoassay. As a result, it was found that electro-acupuncture has no significant long-term analgesic effect on experimental arthritis in rats and has no effect on inflammation. The hypothalamus and pituitary MEK contents in normal rats were 250.43±40.40 pg/mg and 297.81±39.00 pg/mg, respectively. The arthritis group was 160.54±32.25 and 228.85±31.18 pg/mg, respectively, which was significantly lower than normal (P<0.01). The MEK content in the electroacupuncture group was 251.00±38.46 and 286.36±41.92 pg/mg, respectively. It can be seen that electroacupuncture can increase the MEK content in the thalamus and pituitary of arthritis rats (P<0.01).