[目的]探讨过敏性紫癜(HSP)患儿血清IgA1 异常糖基化水平及其与氧化应激指标的相关性.[方法]116 例在本院接受治疗的 HSP患儿,其中单纯 HSP患儿79例,过敏性紫癜肾炎(HSPN)患儿 37 例.选取同期体检的健康儿童30例为对照组.比较三组患儿血清IgA1 和IgA1 异常糖基化水平,血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSHPX)、丙二醛(MDA)和晚期氧化蛋白产物(AOPPs)水平,并分析其相关性.[结果]对照组 IgA1 和 IgA1 异常糖基化水平低于单纯 HSP组和 HSPN组,而单纯 HSP组又低于 HSPN组,且差异均有显著性(均P ＜0.05).对照组SOD、GSHPX水平高于单纯 HSP组和 HSPN组,而单纯 HSP组又高于 HSPN组;对照组 MDA、AOPPs水平低于单纯HSP组和 HSPN组,而单纯 HSP组又低于 HSPN组(均P ＜0.05).Spearman分析显示 IgA1 和 IgA1 异常糖基化与SOD、GSHPX呈负相关(P＜0.05),与MDA、AOPPs呈正相关(P＜0.05).[结论]HSP患儿血清IgA1 和IgA1 异常糖基化水平升高,且与患儿氧化应激状态存在明显的相关性.“,”[Objective]To investigate the abnormal glycosylation of serum IgA1 in children with Henoch Schonlein purpura(HSP)and reveal the correlation with oxidative stress.[Methods]A total of 116 children with HSP admitted to our hospital included 79 cases of simple HSP (HSP group)and 37 cases of Henoch Schonlein purpura nephritis (HSPN group).Volunteers of 30 healthy children were used as the control group.The levels of abnormal glycosylation of serum IgA1,total serum IgA1,serum superoxide dismutase (SOD),glutathione peroxidase (GSHPX),malondialdehyde (MDA)and advanced oxidation protein product (AOPPs)were measured and compared in the three groups,and their correlations were analyzed.[Results]The serum IgA1 and abnormal glycosylation levels of IgA1 in the control group were lower than those in both HSP group and HSPN group,while the HSP group levels were lower than those of the HSPN group;the differences were statisti cally significant (P ＜0.05).The levels of SOD and GSHPX in the control group were higher than those in the HSP group and the HSPN group;and the levels in the HSP group were higher than those in the HSPN group.The levels of MDA and AOPPs in the control group were lower than those in the HSP group and the HSPN group;and levels of the HSP group were lower than those of the HSPN group (P ＜0.05).Spearman analysis showed that IgA1 and the abnormal glycosylation of IgA1 were negatively correlated with SOD and GSHPX (P＜0.05),but positively correlated with MDA and AOPPs (P＜0.05).[Conclusion]The levels of IgA1 and abnormal glycosylation of serum IgA1 in children with HSP are high,which are significant correlation with oxidative stress.