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目的了解杭州市止泻药品销量监测结果与全市腹泻症状发病数的相关性,探讨药品销量监测与传染病发病的关系及其应用。方法搜集杭州市华东武林大药房2006—2012年克痢莎、黄连素及思密达3种非处方止泻药品的销售数据并标化。统计杭州市9家医院的感染性腹泻及非感染性腹泻发病数,分别与药品销量作相关性分析。结果 2006—2012年监测期间,黄连素日销量标化的用药天数(DDD)最大,DDD中位数为1 600.32。2007、2008及2012年止泻药销量DDD高峰出现在7月,2006、2009及2010年高峰出现在8月。相关性分析结果显示:2006、2007、2008及2010年的药品销量与感染性腹泻呈正相关,相关系数分别为0.635、0.448、0.298及0.217(P均<0.01)。7年总的相关系数为-0.555(P<0.01)。2006—2008年的非感染性腹泻发病数与药品销量也呈正相关,3年总的相关系数为0.419(P<0.01)。结论杭州市药品销量监测系统中止泻药销量与感染性及非感染性腹泻均呈正相关,表明药品销量监测对于早期发现肠道病暴发流行有积极作用。
Objective To understand the relationship between the monitoring results of anti-diarrhea drugs in Hangzhou and the incidence of diarrhea in the city and to explore the relationship between drug sales monitoring and the incidence of infectious diseases and its application. Methods The data of sales of 3 kinds of over-the-counter antidiarrheal drugs such as Crassula, berberine and Smectite from Wudarin Pharmacy in Huadong, Hangzhou City in 2006-2012 were collected and standardized. The incidence of infectious diarrhea and non-infectious diarrhea in 9 hospitals in Hangzhou were statistically analyzed, and the correlations were analyzed respectively with the sales volume of drugs. Results During the monitoring period from 2006 to 2012, the daily DDD of berberine was the largest, with the median of DDD being 1 600.32.2007,2008 and the peak DDD of sales of diarrhea drug in 2012 appeared in July, 2006 and 2009 The peak in 2010 appeared in August. Correlation analysis showed that there was a positive correlation between drug sales volume and infectious diarrhea in 2006, 2007, 2008 and 2010 with correlation coefficients of 0.635, 0.448, 0.298 and 0.217 respectively (all P <0.01). The overall 7-year correlation coefficient was -0.555 (P <0.01). The number of non-infectious diarrhea in 2006-2008 also showed a positive correlation with the sales volume of drugs, with a total correlation coefficient of 0.419 at 3 years (P <0.01). Conclusion The sales volume of antidiarrheal drugs in Hangzhou drug sales monitoring system is positively correlated with both infectious and noninfectious diarrhea, indicating that drug sales monitoring plays a positive role in early detection of the outbreak of intestinal diseases.