解救镁盐中毒之措施,自1908年 Meltzer 提出以钙盐拮抗以来,殊少进展。我们在动物实验中探索以4—氨基吡啶(4—AP)解救急性镁盐中毒之可能性.在麻醉猫,4—AP 能解除镁盐中毒时出现的低血压、呼吸抑制和骨骼肌麻痹等症状。在小白鼠,4—AP 能显著提高硫酸镁的 LD_(50)值,与钙盐有协同作用。静注4-AP 能使硫酸镁 The measure to rescue magnesium poisoning has made little progress since Meltzer proposed the antagonism of calcium salts in 1908. We explored the possibility of using 4-aminopyridine (4-AP) to rescue acute magnesium poisoning in animal experiments, such as hypotension, respiratory depression and skeletal muscle paralysis caused by anesthesia cats and 4-AP symptom. In mice, 4-AP can significantly increase the LD_ (50) value of magnesium sulfate, and synergistic effect with calcium salt. Intravenous 4-AP can make magnesium sulfate