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本研究观察大鼠失血性休克时血浆和肝脏溶酶体酶——α-D-甘露糖苷酶(α-M)含量的变化和超氧化物歧化酶(SOD)对这一变化的影响。结果表明:①失血性休克时血浆和肝脏游离型α-M活性均显著升高,相关分析提示肝细胞溶酶体酶释放是血浆溶酶活性升高的原因之一;②SOD能明显降低休克时血浆和肝脏游离α-M的活性。肝细胞超微结构的改变佐证了这一生化学变化。本研究提示超氧阴离子自由基(?)在休克发病中可能起重要作用。
This study was conducted to observe the change of plasma and liver lysosomal enzyme-α-D-mannosidase (α-M) content and the effect of superoxide dismutase (SOD) on this change in rats with hemorrhagic shock. The results showed that: 1 The activities of free α-M in plasma and liver increased significantly after hemorrhagic shock. The correlation analysis suggested that the release of lysosomal enzymes from liver cells was one of the reasons for the increase of plasma lyase activity; 2 SOD could significantly reduce the shock Plasma and liver free α-M activity. Changes in the ultrastructure of hepatocytes support this biochemical change. This study suggests that superoxide anion free radicals (?) may play an important role in the onset of shock.