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目的通过检测类风湿关节炎(RA)患者血清中表皮生长因子(EGF)的水平,探讨其在RA发病过程中存在的意义。方法将研究对象分为RA组和健康对照组,用酶联免疫吸附试验(ELISA)测定两组血清中EGF水平。同时测定RA患者的类风湿因子(RF)、红细胞沉降率(ESR)和C反应蛋白(CRP)。用统计学分析EGF在各组血清中的变化及其与临床各项指标间的相关性。结果 RA组血清EGF水平较正常对照组显著升高(P<0.05)。骨质破坏组血清EGF水平较单纯骨质疏松组显著升高(P<0.05)。RA组EGF水平与RF,ESR,CRP水平比较无显著相关性(P>0.05)。结论血清EGF水平在RA组明显升高,在骨质破坏组尤为明显。提示EGF在诊断RA中有一定价值,可能部分地参与RA的发病过程。
Objective To detect the level of epidermal growth factor (EGF) in the serum of patients with rheumatoid arthritis (RA) and explore its significance in the pathogenesis of RA. Methods The subjects were divided into RA group and healthy control group, and the levels of EGF in serum of the two groups were measured by enzyme linked immunosorbent assay (ELISA). Rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured in RA patients. The statistical analysis of EGF in serum of each group and its correlation with clinical indicators. Results The level of serum EGF in RA group was significantly higher than that in normal control group (P <0.05). The level of serum EGF in osteoporosis group was significantly higher than that in osteoporosis group (P <0.05). There was no significant correlation between EGF level and RF, ESR and CRP levels in RA group (P> 0.05). Conclusion Serum EGF levels were significantly increased in RA group, especially in the group of bone destruction. It is suggested that EGF has some value in the diagnosis of RA and may be partially involved in the pathogenesis of RA.