随着分子生物学技术的发展,出现了流行病学的分支学科——分子流行病学,分子流行病学在解决暴露与结局之间的“黑箱”问题显现出其独特的作用。目前,基因组学、转录组学、蛋白质组学和代谢组学等新知识和新技术的产生及发展为流行病学病因研究的进一步拓展提供了基础。近几年出现的系统流行病学(systems epidemiology)就是在这样的背景下产生的,其必将在复杂疾病病因的研究中起到越来越重要的作用。 With the development of molecular biology, molecular epidemiology and molecular epidemiology have emerged as unique branches of medicine in solving the “black box” problem between exposure and outcome. At present, the emergence and development of new knowledge and new technologies such as genomics, transcriptomics, proteomics and metabolomics provide the basis for the further development of epidemiological etiology. The emergence of systems epidemiology in recent years has come under such a background that it is bound to play an increasingly important role in the study of the etiology of complex diseases.