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尽管胰岛素疗法和口服降血糖药能极大地降低糖尿病人的死亡率,但病人会产生一些并发症,以往的研究表明这些并发症的病因与山梨糖醇途径有关,此途径包括两步协同的酶促反应,醛糖还原酶在其中起启动作用。因此醛糖还原酶抑制剂能有效地治疗和预防这些并发症。 有关黄酮化合物在体外具有抑制醛糖还原酶的作用已有报道,本文研究其在体内条件下的此特性。给9周龄的成年雌性大鼠腹
Although insulin therapy and oral hypoglycaemic agents can significantly reduce the mortality rate of people with diabetes, some complications may occur. Previous studies have shown that the etiology of these complications is related to the sorbitol pathway. This pathway involves a two-step synergistic enzyme. Promote the reaction, aldose reductase in which to start the role. Therefore, aldose reductase inhibitors can effectively treat and prevent these complications. The role of flavonoids in inhibiting aldose reductase in vitro has been reported. This study investigated its characteristics under in vivo conditions. 9 weeks old adult female rat ventral