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氧化新喹(Neoquinoxide)是1979年合成的新型化合物。对本品的机理研究与临床验证均显示对CTX·5FU有增效作用。本文进一步通过对小鼠S—180移植瘤治疗观察到,氧化新喹50mg～100mg/kg灌胃或5FU 10mg/kg腹腔注射均为无抑瘤率剂量,但组织学有变性、水肿及坏死。而同样剂量两者合用,却使抑瘤率增至38.7％。而CTX 10mg/kg腹腔注射的抑瘤率仅为25.03％,若与氧化新喹合用可提高到38.4％及48.3％。透射电镜並观察到增效组的肿瘤细胞有严重的变性、水肿、出血、坏死及自溶现象,且均明显严重过于单一用药各组的改变。特别是加用氧化新喹的各组都可观察到具有直接杀伤瘤细胞的T淋巴细胞及其明显的浸润现象。提示氧化新喹可能有增强细胞免疫活性的作用。
Neoquinoxide is a new compound synthesized in 1979. Mechanistic studies and clinical validation of this product have shown synergistic effects on CTX·5FU. In this article, we further observed the treatment of mice with S-180 tumors. The doses of 50 mg to 100 mg/kg ibuprofen or 5FU 10 mg/kg intraperitoneally to neo-oxide were all doses without tumor inhibition, but histological degeneration, edema, and necrosis were observed. The combination of the same dose increased the rate of tumor inhibition to 38.7%. The inhibitory rate of CTX 10mg/kg intraperitoneal injection was only 25.03%, if combined with oxidized neohydrazine can be increased to 38.4% and 48.3%. Transmission electron microscopy and observation of the synergistic group of tumor cells have severe degeneration, edema, hemorrhage, necrosis and autolysis phenomenon, and were significantly more severe than the single use of drug changes in each group. In particular, T lymphocytes with direct killer tumor cells and their marked infiltration were observed in each group supplemented with neoquinone oxide. It is suggested that the oxidation of nequinta may enhance the cellular immune activity.