论文部分内容阅读
目的研究黄芩苷对卡氏肺孢子虫肺炎(PCP)大鼠血清和肺组织匀浆超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的影响,探讨中药黄芩苷对PCP大鼠的抗氧化作用。方法给SD大鼠皮下注射地塞米松磷酸钠建立PCP动物模型,观察黄芩苷对PCP模型建立前后肺组织病理及血清和肺组织中SOD活性和MDA含量的影响,研究中药黄芩苷对PCP大鼠的抗氧化作用。结果黄芩苷可使大鼠肺组织炎症明显减轻,血清和肺组织中SOD活性高剂量组分别为(1075.69±9.91)和(1235.73±202.52)U/mL,显著高于模型组的(664.14±245.76),(290.20±39.68)U/mL;MDA含量分别为(1.67±0.57),(1.73±0.35)nmol/(mgprot)显著低于模型的(8.46±0.78)和(28.00±7.43)nmol/(mgprot)。结论黄芩苷对PCP大鼠具有一定的抗氧化作用,能够降低MDA含量和升高SOD活性,减轻炎症反应。
Objective To study the effects of baicalin on serum superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in serum and lung homogenate of rats with Pneumocystis carinii pneumonia (PCP) and to explore the effects of baicalin on PCP rats. The antioxidant effect. Methods The animal model of PCP was established by subcutaneous injection of dexamethasone sodium phosphate in SD rats. The effects of baicalin on lung pathology, SOD activity and MDA content in serum and lung tissue before and after the establishment of PCP model were observed. The effects of baicalin on PCP rat were studied. The antioxidant effect. Results Baicalin significantly reduced inflammation in rat lung tissues. The high-dose SOD activity in serum and lung tissues was (1075.69±9.91) and (1235.73±202.52) U/mL, respectively, which was significantly higher than that of the model group (664.14±245.76). ), (290.20±39.68) U/mL; MDA content was (1.67±0.57), (1.73±0.35) nmol/(mgprot) was significantly lower than that of the model (8.46±0.78) and (28.00±7.43) nmol/( Mgprot). Conclusion Baicalin has certain antioxidant effects on PCP rats, which can reduce MDA content and increase SOD activity and reduce inflammation.