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目的探讨盐酸利托君与硫酸镁治疗先兆早产的疗效及安全性。方法先兆早产孕妇136例,随机分为对照组和观察组,每组68例,对照组、观察组分别使用硫酸镁、盐酸利托君加入5%的葡萄糖溶液中静脉滴注,观察两组的疗效和不良反应。结果观察组的治疗总有效率94.1%高于对照组73.5%,差异具有统计学意义(P<0.05)。相比于对照组,观察组的显效时间、保胎成功率、延长妊娠时间、新生儿结局均明显改善,差异具有统计学意义(P<0.05)。两组主要出现呼吸抑制、肌无力、潮热、胸闷、恶心、心悸等不良反应,观察组发生不良反应的例数少于对照组,差异具有统计学意义(P<0.05)。结论盐酸利托君治疗先兆早产疗效较好,不良反应可耐受,值得在临床上推广使用。
Objective To investigate the efficacy and safety of ritodrine hydrochloride and magnesium sulfate in the treatment of threatened preterm labor. Methods Thirty-six pregnant women with threatened preterm labor were randomly divided into control group and observation group, with 68 cases in each group. The control group and observation group were given intravenous drip of 5% dextrose solution with magnesium sulfate and ritodrine hydrochloride respectively. Efficacy and adverse reactions. Results The total effective rate of observation group was 94.1% higher than 73.5% of control group, the difference was statistically significant (P <0.05). Compared with the control group, the effective time of observation group, the success rate of miscarriage, prolonged pregnancy time and neonatal outcome were significantly improved, the difference was statistically significant (P <0.05). There were mainly respiratory depression, muscle weakness, hot flashes, chest tightness, nausea and palpitations in the two groups. There were fewer adverse reactions in the observation group than in the control group (P <0.05). Conclusion Rituximab treatment of threatened preterm labor is better, adverse reactions are tolerable, it is worth to promote the clinical use.