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通过动物实验探讨超微量肝素对微循环保护作用的效果及机制。方法：建立大鼠内毒素休克模型，采用４种观察指标比较６５４２及不同剂量肝素对微循环的作用。结果：超微量肝素治疗后可使内毒素休克大鼠各重要组织微血管通透性分值均有不同程度下降（Ｐ＜００５或００１），血清ＭＤＡ值接近正常对照组，电镜下肠系膜微血管形态基本恢复正常。结论：超微量肝素可有效地改善微循环，且作用优于常规及小剂量肝素，其作用机制可能与抗凝、抗血栓形成以及抗自由基损伤有关。
To explore the effect and mechanism of ultramicro-heparin on the microcirculation protection through animal experiments. Methods: The model of endotoxic shock in rats was established. The effects of 6542 and different doses of heparin on microcirculation were compared using four kinds of observation indexes. Results: The microvascular permeability scores of various important tissues of endotoxic shock rats decreased significantly after treatment with ultra-low-dose heparin (P <005 or 001), serum MDA values were close to those of normal control group. Under electron microscope Mesentery microvascular morphology returned to normal. CONCLUSION: Ultramicro heparin can effectively improve microcirculation and its effect is superior to conventional and low-dose heparin. Its mechanism may be related to anticoagulation, antithrombosis and anti-free radical injury.