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在20％小牛血清-RPMI 1640中培养的细粒棘球蚴原头节经甲苯达唑或阿苯达唑20μg/ml作用3～5d后,其死亡率分别为42.4～64.2％和40.6％。用囊液培养原头节时,两种药物的效果更差。甲苯达唑或阿苯达唑与低浓度的吡喹酮合并应用时,原头节的死亡率较两药单用的明显增加。小鼠1次口服甲苯达唑或阿苯达唑1g/Kg后4h,其血清具有较强的抗原头节作用。
The mortality rate of Echinococcus granulosus cultured in 20% fetal bovine serum-RPMI 1640 after treatment with mebendazole or albendazole 20μg / ml for 3 ~ 5 days were 42.4-64.2% and 40.6% . When cytoplasm is used to culture protocelliils, the effects of both drugs are worse. Mebendazole or albendazole combined with low concentrations of praziquantel, the original head of the mortality rate was significantly increased compared with the two drugs alone. Mice after 1 oral mebendazole or albendazole 1g / Kg after 4h, the serum has a strong antigenic head section.