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目的:初步评估经口内镜下幽门肌切开术(gastric peroral endoscopic pyloromyotomy，G-POEM)治疗先天性肥厚性幽门狭窄(congenital hypertrophic pyloric stenosis，CHPS)的疗效和安全性。方法:回顾西安市儿童医院2019年1—9月期间接受G-POEM治疗的6例CHPS患儿的临床资料，总结手术情况、围手术期管理以及手术相关并发症发生情况等。结果:6例CHPS患儿平均日龄54.5 d(27～130 d)，均顺利完成G-POEM，平均手术时间49.5 min(34～150 min)，术后均未出现发热、消化道出血及腹腔脓肿，平均住院时间12.5 d(10～22 d)。6例术后平均随访4.2个月(3.3～8.6个月)。术后1个月幽门平均直径1.1 cm(0.9～1.5 cm)，较术前的0.3 cm(0.1～0.5 cm)明显扩张。术后1个月体重平均增加0.9 kg(0.4～1.6 kg)，术后3个月体重平均增加3.2 kg(2.6～3.5 kg)，术后3个月随访时患儿体重接近同龄儿的标准体重。结论:初步证实G-POEM治疗婴幼儿CHPS安全、有效，可成为CHPS治疗方式的一种新选择。“,”Objective:To evaluate the efficacy and safety of gastric-peroral endoscopic pyloromyotomy (G-POEM) for congenital hypertrophic pyloric stenosis (CHPS).Methods:Clinical data of 6 CHPS children who received G-POEM treatment in Xi′an Children′s Hospital from January 2019 to September 2019 were collected. Their operative data, perioperative management and procedure-related complications were summarized.Results:The 6 children had mean daily age of 54.5 d (27-130 d). All of them successfully completed G-POEM, with mean operation time of 49.5 min (34-150 min). No postoperative fever, gastrointestinal bleeding or abdominal abscess occurred. The mean hospitalization time was 12.5 d (10-22 d). The mean follow-up time was 4.2 months (3.3-8.6 months). After one-month postoperative follow-up, the pylorus showed obvious dilation to 1.1 cm (0.9-1.5 cm) compared with that before treatment of 0.3 cm ( 0.1-0.5 cm). After one-month and three-month postoperative follow-up, the mean body weight of the children increased by 0.9 kg (0.4-1.6 kg) and 3.2 kg (2.6-3.5 kg), respectively. After three months of postoperative follow-up, all children reached the standard body weight.Conclusion:G-POEM for infant CHPS is safe and effective, which could be a new option.