论文部分内容阅读
研究目的:肝脏的纤维化进程改变肝脏组织的流变属性。创新要点:本文利用剪切黏弹性模量描绘并比较了大鼠肝脏F0期到F4期的纤维化过程。研究方法:两个黏弹性模型,即Zener模型和Voigt模型用于解释流变力学测试得到的实验数据,由此得到每个纤维化分期的肝脏弹性和黏性值。重要结论:肝脏中度纤维化(≤F2期)与黏弹性值密切相关。Zener模型的弹性均值E1从F0期的(0.452±0.094)kPa增加到F2期的(1.311±0.717)kPa,而Voigt模型的弹性均值E从F0期的(0.618±0.089)kPa增加到F2期的(1.701±0.844)kPa。Zener模型的黏性均值从F0期的(3.499±0.186)Pa·s增加到F2期的(4.947±1.811)Pa·s,而Voigt模型的黏性均值从F0期的(3.379±0.316)Pa·s增加到F2期的(4.625±1.296)Pa·s。无论选用哪个黏弹性模型,在F1期和F2期,肝脏弹性值的标准差比黏性值的标准差变化要小。因此,测得的弹性比黏性更有效地区分肝纤维化F0期到F2期。
Research purposes: Liver fibrosis changes the rheological properties of liver tissue. Innovative points: In this paper, shear viscoelastic modulus was used to depict and compare fibrosis in F0 to F4 of rat liver. Research Methods: Two viscoelastic models, the Zener model and the Voigt model, were used to interpret experimental data from rheological mechanics tests to derive liver elasticity and viscosity values for each fibrosis stage. Important conclusion: Liver fibrosis (≤F2 stage) is closely related to the value of viscoelasticity. The elastic mean E1 of the Zener model increased from (0.452 ± 0.094) kPa in F0 period to (1.311 ± 0.717) kPa in F2 period, while that of Voigt model increased from (0.618 ± 0.089) kPa in F0 period to F2 period (1.701 ± 0.844) kPa. The mean value of viscosity of Zener model increased from 3.499 ± 0.186 Pa · s in F0 period to 4.947 ± 1.811 Pa · s in F2 period while that of Voigt model increased from 3.379 ± 0.316 Pa · s in F0 period s increased to F2 (4.625 ± 1.296) Pa · s. Regardless of which viscoelastic model is chosen, the standard deviations of liver elasticities change less than the standard deviations of viscosities at F1 and F2. Therefore, the measured elasticity is more effective in distinguishing liver fibrosis from F0 to F2 than viscous.