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目的 研究普伐他汀与维生素C、E联合治疗更年期妇女高脂血症。方法 180例更年期妇女高脂血症患者 ,按血脂水平分层随机 1∶1∶1比例分成 3组 ,一组服普伐他汀 6 0例 ,一组服维生素C、E6 0例 ,另一组为同时服用普伐他汀和维生素C、E。疗程为 16周 ,服药前、服药 8周、服药 16周分别测血脂。结果 治疗前后普伐他汀组、维生素C、E组、联合组TC分别下降 2 5 .1%、16 .6 %、2 8.9% (P均 <0 .0 0 1) ;TG分别下降 2 3.2 %、2 9.2 %、31.2 %(P均 <0 .0 0 1) ;LDL c分别下降 2 2 .8%、2 0 .5 %、34 .7% (P均 <0 .0 0 1) ;(TC—HDL c) /HDL c分别下降 2 9.9%、2 3.2 %、39.2 % (P <0 .0 0 1)。联合组较另两组降血脂作用强且副作用小 ,普伐他汀组有 3例CK增高但无临床症状。结论 普伐他汀与维生素C、E治疗更年期妇女高脂血症有效 ,对长期用他汀类药物的患者可间断用药 ,减少药物副作用。
Objective To study the treatment of hyperlipidemia in menopausal women with pravastatin and vitamin C and E. Methods One hundred and eighty menopausal women with hyperlipidemia were randomly divided into three groups according to the level of serum lipid: 1: 1: 1 pravastatin, one group received vitamin C and E6, and the other group To take pravastatin and vitamin C, E at the same time. Treatment for 16 weeks, before taking the medication for 8 weeks, taking 16 weeks were measured lipid levels. Results Before and after treatment, the TC in pravastatin group, vitamin C group and E group decreased by 21.5%, 16.6% and 29.9% (P <0.01), respectively; the TG decreased by 3.2% , 21.2%, 31.2%, respectively (all P <0.01); LDLc decreased by 2.2.8%, 20.5%, 34.7% (P < TC-HDL c) / HDL c decreased by 29.9%, 22.2% and 39.2%, respectively (P <0.001). Compared with the other two groups, the combination group had strong anti-hyperlipidemic effect and little side effects. In the pravastatin group, CK increased but no clinical symptoms in 3 cases. Conclusions Pravastatin and vitamins C and E are effective in treating hyperlipidemia in menopausal women. Intermittent drug use can be discontinued in long-term statin-use patients to reduce drug side effects.