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目的:了解院内产超广谱β-内酰胺酶(ESBLs)的大肠埃希菌、肺炎克雷伯菌感染的临床用药情况。方法:对我院2005年460株产ESBLs的大肠埃希菌、肺炎克雷伯菌的药敏情况及抗生素应用情况进行回顾性分析。结果:我院产ESBLs的大肠埃希菌和肺炎克雷伯菌感染主要集中在呼吸科、重症监护病房及神经外科。经验用药应用最多的是左氧氟沙星,其次为头孢哌酮/舒巴坦;药敏报告后用药主要为碳青霉烯类,其次为左氧氟沙星及头孢哌酮/舒巴坦。药物联用以二联应用为主,最多达六联。结论:我院治疗用药中大部分是有效合理的,但也存在不合理、不规范应用现象,应引起重视。
Objective: To understand the clinical application of ESBLs-producing Escherichia coli and Klebsiella pneumoniae in hospital. Methods: In our hospital in 460 ESBLs - producing Escherichia coli, Klebsiella pneumoniae drug susceptibility and antibiotic applications were retrospectively analyzed. Results: In our hospital, ESBLs-producing Escherichia coli and Klebsiella pneumoniae infections mainly concentrated in respiratory department, intensive care unit and neurosurgery. Levofloxacin was the most frequently used empirical drug, followed by cefoperazone / sulbactam. The drugs used for drug sensitivity were mainly carbapenems, followed by levofloxacin and cefoperazone / sulbactam. Drug combination to two main applications, up to six. Conclusion: Most of the drugs used in our hospital are effective and reasonable, but there are also unreasonable and irregular application phenomena, which should be paid more attention to.