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目的 研究口腔鳞癌对不同给药途径的术前诱导化疗的疗效以及与多药耐药基因表达水平的关系。方法 将98例口腔鳞癌初诊患者随机分为3组:①术前未化疗组;②术前常规静脉给药化疗组;③术前动脉局部灌注化疗组,分别观察治疗疗效,并用免疫组化方法检测多药耐药基因编码的蛋白产物P-糖蛋白(P-gp)表达水平与术前化疗的关系。结果 动脉局部灌注化疗组疗效优于常规静脉给药化疗组(P<0.05),未行化疗组口腔鳞癌组织P-gp阳性率为42.3％,经术前诱导化疗后癌组织P-gp阳性率显著升高(P<0.05),但不同给药途径的术前诱导化疗对口腔鳞癌组织P-gp表达的影响无显著性差异(P>0.05)。结论 术前化疗后其残留口腔鳞癌细胞的P-gp表达增高,术后最好选择放疗或进行药敏试验后选择化疗药物。
Objective To investigate the effect of oral squamous cell carcinoma on the preoperative chemotherapy induced by different route of administration and its relationship with multidrug resistance gene expression. Methods 98 cases of newly diagnosed oral squamous cell carcinoma patients were randomly divided into three groups: ① preoperative non-chemotherapy group; ② routine preoperative intravenous chemotherapy group; ③ preoperative arterial partial perfusion chemotherapy group, respectively, to observe the therapeutic effect, and immunohistochemistry Methods The expression of P-glycoprotein (P-glycoprotein), which is encoded by multidrug resistance gene, was examined by the method of preoperative chemotherapy. Results The perfusion chemotherapy group was superior to conventional intravenous chemotherapy group (P <0.05). The positive rate of P-gp in oral squamous cell carcinoma was 42.3% in the non-chemotherapy group. After preoperative chemotherapy, the positive expression of P-gp (P <0.05). However, there was no significant difference in the expression of P-gp before and after chemotherapy (P> 0.05). Conclusions The expression of P-gp in residual squamous cell carcinoma of oral squamous cell carcinoma is increased after preoperative chemotherapy. After chemotherapy, it is better to choose radiotherapy or drug susceptibility test.