本文报导113例长期服用氯丙嗪引起的眼部及皮肤色素沉着。药物平均累积量为582.7g,晶状体混浊发病率为71.7％,角膜混浊发病率为50.4％,皮肤色素沉着发生率为70.8％。文章描述了氯丙嗪所致眼和皮肤病变的临床特点,并对发病有关因素、发病机理及治疗作了简要讨论。氯丙嗪所致眼和皮肤病变的发病率与药物剂量的大小有密切关系,但对视力影响不大。 This article reports 113 cases of long-term use of chlorpromazine caused by eye and skin pigmentation. The average cumulative amount of drug was 582.7g, the incidence of lens opacity was 71.7%, the incidence of corneal opacity was 50.4% and the incidence of skin pigmentation was 70.8%. This article describes the clinical features of the eye and skin lesions caused by chlorpromazine, and briefly discusses the pathogenesis, pathogenesis and treatment. The incidence of eye and skin lesions caused by chlorpromazine is closely related to the size of the drug dose, but has little effect on visual acuity.