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目的探索蜕皮激素是否能够减轻肺再灌注损伤。方法应用肺再灌注损伤模型，大鼠颈静脉滴注蜕皮甾酮（３０ｍｇ·ｋｇ－１），并与氢化可的松（１０ｍｇ·ｋｇ－１）相比较，检测动脉血气，测定肺组织血管紧张素转化酶（ＡＣＥ）、丙二醛（ＭＤＡ）及超氧化物岐化酶（ＳＯＤ）的含量，光镜观察肺组织及微血管变化。结果蜕皮甾酮组ＰａＯ２、ｐＨ及ＨＣＯ－３均较损伤对照组明显增高。ＡＣＥ及ＭＤＡ在蜕皮甾酮组明显低于损伤对照组，亦低于氢化可的松对照组。ＳＯＤ则蜕皮甾酮组较损伤对照组明显增高，亦较氢化可的松对照组为高。光镜显示，蜕皮甾酮组的肺组织水肿、微血管腔变窄、内皮肿胀等较损伤对照组明显减轻，而与氢化可的松对照组相似。结论蜕皮甾酮可减轻再灌注时肺血管内皮细胞损伤，对肺再灌注损伤有一定的防治作用，效果不亚于氢化可的松，其机制有待进一步研究。
Objective To explore whether ecdysone can reduce lung reperfusion injury. Methods The model of pulmonary reperfusion injury was established. The rats were injected with ecdysterone (30 mg · kg-1) into the jugular vein and compared with hydrocortisone (10 mg · kg-1) (ACE), malondialdehyde (MDA) and superoxide dismutase (SOD) were detected by light microscopy. The changes of lung tissue and microvessels were observed by light microscope. Results The ecdysterone group PaO2, pH and HCO-3 were significantly higher than the injury control group. ACE and MDA were significantly lower in the ecdysterone group than in the injury control group and also lower than that in the hydrocortisone control group. SOD ecdysterone group than the injury control group was significantly higher than the hydrocortisone control group. Light microscopy showed that the ecdysterone group of lung tissue edema, microvascular lumen narrowing, endothelial swelling and other damage than the control group significantly reduced, but similar with hydrocortisone control group. Conclusion Ecdysterone can reduce the injury of pulmonary vascular endothelial cells during reperfusion, and has a certain preventive and therapeutic effect on lung reperfusion injury, with the same effect as hydrocortisone. The mechanism remains to be further studied.