作者实验室先前所从事的研究表明,在B-CLL的病程中发生自身免疫性溶血性贫血(AIHA)的机制可能是因为B-CLL细胞与抗红细胞自身抗体的产生有关。为了验证这一假设,作者尝试将发生AIHA的人类B-CLL输给有免疫缺陷的小鼠。将11例有AIHA的B-CLL患者的外周血单个核细胞(PBMC)移植到经致死量辐射、并用SCID骨髓重建其造血系统的Balb/c小鼠的腹膜腔中。接受了这些患者(病程Ⅲ～Ⅳ度)的 Research previously conducted by the author’s laboratory showed that the mechanism of autoimmune hemolytic anemia (AIHA) during the course of B-CLL may be due to the fact that B-CLL cells are associated with the production of anti-erythrocyte autoantibodies. To test this hypothesis, the authors attempted to lose AIHA-producing human B-CLL to immunocompromised mice. Peripheral blood mononuclear cells (PBMCs) from 11 patients with AIHA-B-CLL were transplanted into the peritoneal cavity of Balb/c mice that were irradiated with lethal doses and reconstituted their hematopoietic system with SCID bone marrow. Accepted these patients (course III to IV)