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目的检测CCR7和EGFR在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达,并分析其与肺癌临床病理特征间的关系,探讨CCR7和EGFR在NSCLC淋巴结转移中的作用。方法选用55例NSCLC临床切除组织石蜡标本,以免疫组化SP法检测CCR7和EGFR的表达。结果55例肺癌组织中,CCR7阳性表达37例,阳性率为67.2%(37/55),EGFR阳性表达40例,阳性率为72.7%(40/55),二者的表达与淋巴结转移存在非常显著相关性。结论CCR7和EGFR在NSCLC组织中高表达,且其表达与NSCLC淋巴结转移密切相关。
Objective To detect the expression of CCR7 and EGFR in non-small cell lung cancer (NSCLC) tissues and to analyze its relationship with clinicopathological characteristics of lung cancer and to explore the role of CCR7 and EGFR in lymph node metastasis of NSCLC. Methods Seventy-five paraffin sections of NSCLC specimens were selected for histological examination. The expressions of CCR7 and EGFR were detected by immunohistochemical SP method. Results Among the 55 cases of lung cancer, 37 were positive for CCR7, the positive rate was 67.2% (37/55), the positive rate of EGFR was 40 (40/55), and the positive rate of CCR7 was 40.7% Significant correlation. Conclusion CCR7 and EGFR are highly expressed in NSCLC tissues, and their expression is closely related to lymph node metastasis in NSCLC.