论文部分内容阅读
炎症性肠病(IBD)主要是一组反复发作的慢性非特异性肠道炎症性疾病,包括克罗恩病和溃疡性结肠炎。IBD发病时,肠黏膜屏障功能异常,抗原移位刺激免疫细胞,产生大量炎性细胞因子及介质,炎性分子破坏紧密连接,加剧损伤肠黏膜屏障功能。通过保护肠上皮细胞骨架、修复上皮细胞及细胞间紧密连接能改善肠上皮屏障功能,这也是当前临床治疗IBD的新策略和新思路。
Inflammatory bowel disease (IBD) is mainly a group of recurrent chronic non-specific intestinal inflammatory diseases, including Crohn’s disease and ulcerative colitis. IBD pathogenesis, intestinal mucosal barrier dysfunction, antigen displacement stimulate the immune cells, produce a large number of inflammatory cytokines and media, inflammatory molecules destroy the tight junction, aggravating the damage of intestinal mucosal barrier function. It is also a new strategy and new idea for clinical treatment of IBD by protecting the intestinal epithelial cytoskeleton, repairing epithelial cells and tight junctions between cells and improving intestinal barrier function.