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目的观察泮托拉唑在临床中应用的安全性,以提高第三代质子泵抑制剂药物的临床应用水平。方法选取服用泮托拉唑的胃炎患者2500例和服用奥美拉唑的胃炎患者2500例,观察2组药物不良反应发生情况、老年患者的不良反应发生率、长期治疗患者的不良反应发生率。结果泮托拉唑组不良反应的发生率低于奥美拉唑组(P<0.05);老年患者的不良反应发生率不高于年轻患者;长期服药患者的不良反应未见增高。结论泮托拉唑可以安全高效快速抑制胃酸分泌,值得临床推广应用。
Objective To observe the safety of pantoprazole in clinical application and to improve the clinical application of the third generation proton pump inhibitor drugs. Methods 2500 patients with gastritis taking pantoprazole and 2500 patients with gastritis taking omeprazole were enrolled in this study. The incidence of adverse drug reactions, the incidence of adverse reactions in elderly patients and the incidence of adverse reactions in long-term patients were observed. Results The incidence of adverse reactions in the pantoprazole group was lower than that in the omeprazole group (P <0.05). The incidence of adverse reactions in the elderly patients was not higher than that in the young patients. There was no increase in adverse reactions in the long-term medication. Conclusions Pantoprazole can inhibit gastric acid secretion rapidly and safely, which is worthy of clinical application.