目前,帕金森病的发病机理存在各种假说,包括氧化应激与清除自由基能力下降、线粒体功能异常、兴奋性氨基酸的毒性作用、神经营养因子的缺乏、神经炎症机制、基因与环境影响因素、一氧化氮毒性作用和凋亡等。本文就帕金森病的氧化应激、环境影响因素、神经炎症机制作一综述。 At present, there are various hypotheses about the pathogenesis of Parkinson’s disease, including decreased oxidative stress and free radical scavenging, abnormal mitochondrial function, toxic effects of excitatory amino acids, lack of neurotrophic factors, neuroinflammation mechanisms, genetic and environmental factors , Nitric oxide toxicity and apoptosis. This article reviews the oxidative stress, environmental factors and neuroinflammation mechanism of Parkinson’s disease.