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近年国外已将纳络酮(Naloxone)广泛用于临床,它的治疗作用很多。本文重点对其治疗新生儿窒息方面作一概述。一、纳络酮的概述十多年前发现中枢神经系统(CNS)有吗啡受体后,有人进一步提出CNS存在三种吗啡受体[μ(mu)、K(kappa)、δ(sigma)]。近年在心、肝、肾和小肠也发现这些受体。这些受体能与内源性吗啡样物质(如β-内啡肽等)亲密结合。
In recent years, naloxone has been widely used in clinical practice abroad, and its therapeutic effects are numerous. This article focuses on its treatment of neonatal asphyxia in an overview. First, the overview of naloxone Ten years ago found that the central nervous system (CNS) has morphine receptors, it was further suggested that CNS there are three morphine receptors [mu (kappa), sigma] . In recent years, these receptors have also been found in heart, liver, kidney and small intestine. These receptors bind intimately with endogenous morphine-like substances (such as beta-endorphin, etc.).