目的 :探讨新生儿败血症治疗前后心肌酶值变化的临床意义 ,以指导临床治疗。方法 :6 9例新生儿败血症 ,分别在治病前及治疗后 2周测定心肌酶值 ,5 3例作心电图检查。结果 :①新生儿败血症治疗前心肌酶值 1 0 0 %增高 :治疗后心肌酶值全部下降 ,治疗前后对比 ,有显著差异 (P <0 .0 5 )。②同时查心电图治疗前后对比 ,有显著性差异 (p <0 .0 5 )。③心肌酶增高与胎龄无关 ,足月儿与早产儿败血症患儿心肌酶值经统计学处理无显著差异 (p >0 .0 5 )。结论 :新生儿败血症有心肌细胞的损害 ,经积极抗感染和营养心肌治疗 2周后复查 ,心肌酶值全部下降 ,心电图恢复正常 ,考虑心肌损害为可逆性。 Objective: To investigate the clinical significance of myocardial enzyme changes before and after neonatal sepsis to guide clinical treatment. Methods: Ninety-nine neonates with sepsis were enrolled. Myocardial enzyme values ​​were measured before treatment and 2 weeks after treatment, respectively. 53 cases were examined by electrocardiogram. Results: (1) Neonatal sepsis before treatment increased 100% of myocardial enzymes: all the enzyme values ​​decreased after treatment, before and after treatment, there was a significant difference (P <0.05). ② at the same time check the ECG before and after treatment, there was a significant difference (p <0. 05). ③ increased myocardial enzymes has nothing to do with gestational age, full-term children and premature children with sepsis myocardial enzyme values ​​were statistically no significant difference (p> 0.05). Conclusion: Neonatal sepsis has damage of cardiomyocytes. After 2 weeks of active anti-infective and nutritional myocardial therapy, the myocardial enzymes were all decreased and the electrocardiogram returned to normal. The myocardial damage was considered reversible.