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现代的放疗与化疗治疗早期何杰金病(HD)已获良效,无病10年存活率可达80%以上。但是可引起包括性腺功能减退的副作用。本文研究了经第1次治疗后长期缓解的16例早期HD年轻女患者的生育能力及激素状态。该16例均在40岁前接受标准治疗:全部病例都给予斗蓬式照射,总剂量40GY,并对每一患者随机地加给膈下淋巴结照射(总剂量为33～40GY的倒Y字式或总剂量为40GY的主动脉旁式),或6个疗程的MOPP(平均累积量:氮芥59.6mg/M~2,长春新碱8.0mg/M~2,甲基苄肼6.0g/M~2,强的松1.1g/M~2)。治疗结束后均持续缓解至少4年(48～123个月,平均76个月)。全部患者的催乳激素值及甲状腺素值均正常。
Modern radiotherapy and chemotherapy early Hodgkin’s disease (HD) has been good, disease-free 10-year survival rate of up to 80%. But can cause side effects that include hypogonadism. This article investigates fertility and hormone status in 16 early HD young women who have long-term remission after the first treatment. The 16 patients were all treated 40 years before receiving standard treatment: All cases were given a cappella, a total dose of 40 Gy, and each patient was randomly assigned to subphrenic lymph node irradiation (total dose of 33-40GY inverted Y-shaped Or a total of 40 Gy of aorta), or 6 courses of MOPP (mean cumulative amount: nitrogen mustard 59.6mg / M ~ 2, vincristine 8.0mg / M ~ 2, procarbazine 6.0g / M ~ 2, prednisone 1.1g / M ~ 2). After treatment, sustained relief of at least 4 years (48 to 123 months, an average of 76 months). Prolactin and thyroxine values were normal in all patients.