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目的：研究维拉帕米治疗高血压患者左心舒张功能不全的作用。方法：对２４例高血压患者，应用心动超声（心超）多普勒测定二尖瓣水平舒张早期血流速度曲线峰值（Ｅ）与心房收缩期血流速度曲线峰值（Ａ）及左室射血分数（ＬＶＥＦ），结果：服药５周后心率（ＨＲ）及舒张压（ＤＢＰ）、Ａ值均减低（分别为６９．１８±６．５２与７６．２３±８．７２次／分，８２．６１±８．９５与９８．４４±１０．３４ｍｍＨｇ，６６．３０ ± １４．０４与７３．９４ ± １２．２８ ｃｍ／ｓ，Ｐ均＜０．００１），Ｅ与Ｅ／Ａ值增加（分别７１．４９±９．８４与５２．２２±１１．８９ ｃｍ／ｓ，１．０９１±０．２６与０．７２７±０．１７，Ｐ均＜０．００１）。结论：维拉帕米可显著改善高血压患者的左心舒张功能不全。
Objective: To study the effect of verapamil on left ventricular diastolic dysfunction in hypertensive patients. Methods: Twenty-four hypertensive patients were examined by echocardiography (Echocardiography) and Doppler echocardiography (Doppler) to measure the relationship between peak mitral inflow velocity (E) and atrial systolic peak velocity (A) (LVEF). Results: Heart rate (HR), DBP and A decreased after 5 weeks of treatment (69.18 ± 6.52 vs 76.23 ± 8.72 bpm, respectively .61 ± 8.95 and 98.44 ± 10.34mmHg, 66.30 ± 14.04 and 73.94 ± 12.28 cm / s, P <0.001), and the values of E and E / A increased 71.49 ± 9.84 and 52.22 ± 11.89 cm / s, 1.091 ± 0.26 and 0.727 ± 0.17, respectively, P <0.001). Conclusion: Verapamil can significantly improve left ventricular diastolic dysfunction in hypertensive patients.