目的　探讨Bax和TGFβRⅡ基因在肺癌组织中的移码突变及其与微卫星改变的关系。 方法　用PCR 变性聚丙烯酰胺凝胶电泳 银染法 ,检测 5 0例肺癌组织Bax和TGFβRⅡ基因移码突变及微卫星改变。结果　Bax基因 (G) 8移码突变 12例 ,占 2 4% (12 / 5 0 ) ,主要是碱基丢失。TGFβRⅡ的 (A) 10 未发现移码突变。Bax移码突变与微卫星不稳定和 /或杂合性缺失有密切关系 (P <0 .0 5 )。结论　肺癌组织中存在Bax基因移码突变且与微卫星改变密切相关 ,它们在肺癌发病中可能有一定作用 Objective To investigate the frameshift mutation of Bax and TGFβRⅡ in lung cancer and its relationship with microsatellite alteration. Methods PCR-modified polyacrylamide gel electrophoresis silver staining was used to detect the shift of the Bax and TGFβRⅡ gene mutations and microsatellite changes in 50 lung cancer tissues. Results Bax gene (G) 8 frame shift mutation in 12 cases, accounting for 24% (12/50), mainly loss of base. There was no frameshift mutation in TGFβRII (A) 10. Bax frameshift mutation is closely related to microsatellite instability and / or loss of heterozygosity (P <0.05). Conclusion There is a Bax gene frameshift mutation in lung cancer tissues and is closely related to microsatellite alterations, which may play a role in the pathogenesis of lung cancer