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转基因小鼠制作技术于1980年由Gorden等建立的,现在该方法可以在很多领域应用。我们利用该方法分析了与人类疾病有关的基因及其发病过程,同时还对发育分化有关的基因、未知基因进行了分离试验,现介绍如下: 一、分析显性遗传病的发病机制:家族性淀粉样蛋白多神经病是显性遗传病,通过建立该病的转基因小鼠可知;淀粉样蛋白沉积的组织与人类患者相同,既:肠、肾脏心脏、皮肤、甲状腺等;淀粉样蛋白沉积的开始时间是在出生后6个月时开使的(人类相当于30～40岁);血清淀粉样P蛋白不影响淀粉样蛋白的沉积;环境因素与淀粉样蛋白的沉积有关。
The transgenic mouse production technology was established by Gorden et al. In 1980 and now the method can be applied in many fields. We use this method to analyze the human disease-related genes and their pathogenesis, but also on the development and differentiation of genes, unknown genes were isolated and tested, are described below: First, analysis of dominant genetic disease pathogenesis: familial Amyloid polyneuropathy is a dominant genetic disease, as evidenced by the transgenic mice that established the disease; amyloid deposits in the same tissues as human patients: the gut, the kidneys’ heart, the skin, the thyroid, etc .; the beginning of amyloid deposition Time is 6 months after birth (human equivalent to 30 to 40 years old); serum amyloid P protein does not affect the deposition of amyloid; environmental factors and amyloid deposition.