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目的比较宫颈扩张球囊与控释地诺前列酮栓用于足月妊娠促宫颈成熟的引产效果及不良反应。方法将208例于产科住院待产的单胎头位初产妇随机分为宫颈扩张球囊组(球囊组)118例,控释地诺前列酮栓(欣普贝生)组(药物组)90例,对产妇宫颈成熟、分娩方式、总产程、使用催产素情况、妊娠结局及并发症进行统计分析。结果球囊组与药物组产妇引产前后宫颈Bishop评分、促宫颈成熟有效率、引产成功率和剖宫产率差异均无统计学意义(P>0.05)。球囊组使用缩宫素率高于药物组,子宫过度刺激发生率较药物组明显降低,差异均有统计学意义(P<0.05)。药物组自然临产率明显高于球囊组,总产程明显短于球囊组,差异均有统计学意义(P<0.05)。两组产后出血量、新生儿窒息发生率、羊水粪染发生率差异均无统计学意义(P>0.05)。结论宫颈扩张球囊与控释地诺前列酮栓促宫颈成熟效果相似,控释地诺前列酮栓引产效果优于宫颈扩张球囊,但其安全性低于宫颈扩张球囊。
Objective To compare the induction of labor and side effects of cervical dilation balloon and controlled release dinoprostone suppository for full-term pregnancy-promoting cervical ripening. Methods A total of 208 primiparous primiparas who were hospitalized in obstetrics and gynecology were randomly divided into cervical dilatation balloon group (balloon group) 118 cases, controlled release dinoprostone suppository group (drug group) 90 Cases, maternal cervical maturity, mode of delivery, total labor, the use of oxytocin, pregnancy outcomes and complications for statistical analysis. Results There was no significant difference in Bishop cervical score, cervical ripening efficiency, success rate of induced abortion and cesarean section rate before and after induction of labor in both the balloon group and the drug group (P> 0.05). The oxytocin rate in the balloon group was higher than that in the drug group, and the incidence of uterine over-stimulation was significantly lower than that in the drug group. The difference was statistically significant (P <0.05). The spontaneous labor productivity of the drug group was significantly higher than that of the balloon group, and the total labor was significantly shorter than that of the balloon group (P <0.05). Postpartum hemorrhage, neonatal asphyxia and amniotic fluid meningitis incidence had no significant difference (P> 0.05). Conclusions Cervical dilatation balloon and controlled release droperidol suppository have similar effects on cervical ripening. The controlled release dinorelone suppository is superior to cervical dilatation balloon but its safety is lower than that of cervical dilatation balloon.