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对胃肿瘤浸润淋巴细胞（ＴＩＬ）的分离、制备、扩增、杀瘤活性、表型变化进行研究，对２３例胃癌患者进行生物治疗。结果显示：ＴＩＬ经１５天培养后，杀伤活性达７９％以上，ＴＩＬ的扩增可达９００倍。其收获率、活性与所取瘤组织及转移淋巴结的大小及新鲜程度相关。ＴＩＬ生物治疗晚期胃癌，可使患者瘤体部分缩小，存活期延长，临床症状体征明显改善，免疫功能显著提高，抗癌消瘤能力增强。本研究认为，对于晚期胃癌患者的综合治疗，ＴＩＬ生物治疗是有效方法之一。
The isolation, preparation, amplification, tumoricidal activity and phenotypic changes of gastric tumor-infiltrating lymphocytes (TIL) were studied and 23 patients with gastric cancer were treated biologically. The results showed that the killing activity of TIL was more than 79% after 15 days of culture, and the TIL was amplified 900 times. The harvest rate and activity were related to the size and freshness of the removed tumor tissues and metastatic lymph nodes. TIL biological treatment of advanced gastric cancer can make the tumor part of the patient shrink, prolong survival, clinical symptoms and signs improved significantly, significantly improved immune function, anti-cancer anti-cancer ability. This study believes that TIL biotherapy is one of the effective methods for comprehensive treatment of patients with advanced gastric cancer.