对88例日本类风湿性关节炎患者和104例正常日本人测定了HLA-A、B、C和DR抗原的类型。HLA DR4的频度在患者中占70.5％,正常对照组中则占46.1％(P<0.001)。但患者中,HLA DR4频度的性别差异值得注意。HLA DR4发现于80.6％男性患者,与对照组相比有着很重要的意义(P<0.0005),而在女性患者则仅发现60.5％(P<0.05)的边界线性增高。另 The types of HLA-A, B, C, and DR antigens were determined in 88 Japanese patients with rheumatoid arthritis and 104 normal Japanese. The frequency of HLA DR4 was 70.5% in patients and 46.1% in controls (P <0.001). However, gender differences in the frequency of HLA DR4 are noteworthy in patients. HLA DR4 was found in 80.6% of men with significant significance compared with controls (P <0.0005), whereas only 60.5% (P <0.05) of borderline increases were found in women. another