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目的研究从糖耐量正常、糖耐量低减至糖尿病发展过程中血一氧化氮(NO)、超敏C-反应蛋白(CRP)的变化,探讨其与糖尿病早期动脉硬化颈动脉内膜中层厚度(intimal-medialthickness,IMT)的关系。方法90例患者,其中糖耐量正常、糖耐量低减、2型糖尿病各30例,每例均晚间禁食后抽血行包括NO、CRP在内的生化检查及超声检测颈动脉内膜中层厚度。结果从糖耐量正常、糖耐量低减至糖尿病,随着糖代谢异常的加重,颈动脉内膜中层逐渐增厚、血NO逐渐降低、CRP逐渐升高(P<0.05或P<0.01)。结论糖代谢异常早期即有血管内皮损伤、炎症反应等变化,并参与了糖尿病动脉硬化的整个进程,因此早期控制血糖、稳定血管内皮损伤、抑制炎症反应,对于延缓、减少糖尿病晚期动脉硬化等并发症具有重要的作用。
Objective To study the changes of blood nitric oxide (NO) and high-sensitivity C-reactive protein (CRP) during the period from normal glucose tolerance to low glucose tolerance to the development of diabetes mellitus (DM) intimal-medial thickness, IMT). Methods Ninety patients, including normal glucose tolerance, impaired glucose tolerance and type 2 diabetes mellitus (30 cases), were enrolled in this study. All patients underwent a fasting blood test at the end of the day, including biochemical tests including NO and CRP, and carotid intima-media thickness . Results From normal glucose tolerance and low glucose tolerance to diabetes mellitus, carotid artery intima-media thickness gradually increased, serum NO decreased and CRP increased gradually (P <0.05 or P <0.01). Conclusions There are changes of vascular endothelial injury and inflammatory reaction in the early stage of abnormal glucose metabolism and involved in the whole process of atherosclerosis of diabetes. Therefore, it can control blood sugar early, stabilize the vascular endothelial injury, inhibit the inflammatory reaction, and delay and reduce the occurrence of advanced arteriosclerosis such as diabetes Disease has an important role.