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目的:研究发生于肺的良性转移性平滑肌瘤(BML)的临床病理特点。方法:收集本病1例,分析研究其临床表现、影像学资料、大体形态、组织学形态及免疫组化结果并查阅对照相关文献。结果:本例BML为49岁女性患者,子宫平滑肌瘤术后15年发生肺转移,无全身其他部位转移。组织形态类似于子宫平滑肌瘤,细胞无异型,未找到核分裂象,免疫组化染色结果符合子宫原发。结论:BML是一种罕见的发生于有子宫平滑肌瘤手术史的女性,肺是主要转移部位,呈激素依赖性,定期全身体检是早期发现肿瘤转移的关键。
Objective: To study the clinicopathological features of benign metastatic leiomyoma (BML) occurring in the lung. Methods: One case was collected and its clinical manifestations, imaging data, gross morphology, histological morphology and immunohistochemical results were analyzed and referenced. Results: This case of BML is a 49-year-old female patient. Uterine leiomyomas undergo lung metastases 15 years after surgery and no metastasis to other parts of the body occurs. Histomorphology is similar to that of uterine leiomyoma. The cells are not abnormal and no mitotic figures are found. Immunohistochemical staining results are consistent with the uterine primordial origin. CONCLUSIONS: BML is a rare occurrence in women with a history of uterine leiomyomas. The lung is the main metastatic site and is hormone dependent. A regular full physical examination is the key to early detection of metastases.