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肿瘤组织中存在一小部分具有无限增殖、自我更新和多向分化能力的肿瘤干细胞。这些肿瘤干细胞,普通的放化疗很难将其根除,并成为肿瘤复发的主要原因。在许多针对肿瘤干细胞的治疗方法中,靶向治疗是目前研究的热点。靶向治疗是通过切断肿瘤干细胞传导通路,攻击肿瘤干细胞表面标志物或诱导肿瘤干细胞分化等途径,抑制或根除肿瘤干细胞,其为根治肿瘤开辟了新的研究方向。
There is a small part of tumor tissue with unlimited proliferation, self-renewal and multidrug differentiation of tumor stem cells. These tumor stem cells, ordinary radiotherapy and chemotherapy is difficult to eradicate, and become the main reason for tumor recurrence. Targeted therapies are the current research hotspot in many treatment of cancer stem cells. Targeted therapies inhibit or eradicate cancer stem cells by cutting off cancer stem cell conduction pathways, attacking tumor stem cell surface markers or inducing tumor stem cell differentiation, which opens up a new research direction for radical tumor therapy.