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目的探讨复合溶葡萄球菌酶治疗烧伤后期感染创面的临床效果。方法将我院住院的2010年1月至2010年6月的32例烧伤患者,创面分泌物培养均为耐甲氧西林金黄色葡萄球菌(MR-SA),随机选取同体烧伤深度、创面状态一致的烧伤创面2处,分设治疗组和对照组,治疗组为应用复合溶葡萄球菌酶组,对照组应用碘伏溶液纱布治疗。创面常规清创后,治疗组应用浓度2～3mg/ml的复合溶葡萄球菌酶纱布覆盖在创面上,对照组应用浓度为0.5%碘伏纱布覆盖在创面上,外包无菌敷料,每日换药1次,持续一周。创面做分泌物培养观察培养阴性结果和创面愈合情况,应用t检验做统计学处理。结果连续应用3d后,治疗组绝大部分创面分泌物培养结果转阴,对照组仍为MRSA阳性,连续应用7d后,治疗组创面大部分愈合,对照组创面仍未愈合。结论复合溶葡萄球菌酶消毒剂具有较强的杀灭金黄色葡萄球菌的作用,能有效控制烧伤后期金黄色葡萄球菌的感染。
Objective To investigate the clinical efficacy of complex lysostaphin in the treatment of post-burn infected wounds. Methods Thirty-two burn patients who were hospitalized from January 2010 to June 2010 in our hospital were all exposed to methicillin-resistant Staphylococcus aureus (MR-SA). All patients were randomly selected to have the same depth of burn and the same wound status Burn wounds were divided into treatment group and control group. The treatment group was given Lysozyme group and the control group was treated with iodophor gauze. Wound routine debridement, the treatment group with the concentration of 2 ~ 3mg / ml of the composite lysostaphin gauze covered the wound, the control group with a concentration of 0.5% iodophor gauze covered the wound surface, aseptic dressing outsourcing, daily change Medicine 1 times a week. The wounds were treated with secretions to observe the culture negative results and wound healing, the t test was used to do statistical analysis. Results After 3 days of continuous application, most of the wounds in the treatment group turned negative in culture results. The control group was still positive for MRSA. After 7 days of continuous application, the wounds of the treatment group mostly healed, while the wounds of the control group did not heal. Conclusion The compound lysostaphin disinfectant has a strong effect of killing Staphylococcus aureus and can effectively control the infection of Staphylococcus aureus in the late stage of burn.