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二烷基锌对醛的不对称加成反应是合成手性二级醇的有效方法,产物手性二级醇是药物、精细化学品和天然产物的重要中间体,以不同结构类型的手性配体为依据,综述了近6年来各种手性配体在醛的不对称烷基化反应中的应用.
Asymmetric addition reaction of dialkylzinc to aldehydes is an effective method for the synthesis of chiral secondary alcohols. Chiral secondary alcohols are important intermediates of pharmaceuticals, fine chemicals and natural products. Chiral secondary alcohols with different structure types Based on the ligands, the applications of various chiral ligands in the asymmetric alkylation of aldehydes over the past six years are reviewed.