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选取早期DN患者56例,应用胰岛素强化治疗共4周,结果:尿MA水平与TC(r=0.510,P<0.01)、FPG(r=0.28,P<0.01)、2hPG(r=0.29,P<0.01)、HbA1c(r=0.38,P<0.01)呈正相关。治疗结束时,所有患者血糖和尿MA均达到理想控制,较治疗前明显降低(P<0.01)。结论:胰岛素强化治疗能够减少UMA。
Fifty-six patients with early-stage DN were enrolled in this study. Forty-eight weeks after treatment with insulin-intensive therapy, the levels of urinary MA were significantly correlated with TC (r = 0.510, P <0.01) <0.01), HbA1c (r = 0.38, P <0.01). At the end of treatment, blood glucose and urine MA of all patients reached the ideal control, which was significantly lower than that before treatment (P <0.01). Conclusion: Intensive insulin therapy reduces UMA.