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目的 :研究信宁咳糖浆在镇咳 ,祛痰及其急性毒性方面的药理学作用。方法 :利用浓氨水喷雾法 ,枸橼酸喷雾引咳法 ,毛细玻管引痰法及采用观察小鸭气管纤毛运动的方法来研究信宁咳糖浆在镇咳、祛痰方面的药理作用。结果 :研究证明信宁咳糖浆能促进小鸭呼吸道内腺体分泌和粘液移动及气管纤毛运动 ,能明显增加大鼠排痰量。此外还可明显延长豚鼠和小鼠咳嗽潜伏期 ,减少其咳嗽次数。结论 :信宁咳糖浆具有很好的祛痰止咳作用
Objective: To study the pharmacological effects of Xining cough syrup in antitussive, expectorant and acute toxicity. Methods: The pharmacological effects of Xining cough syrup on antitussive and expectorant were studied by concentrated ammonia spray method, tannic acid spray induced cough method, capillary glass tube pulling method and observation of duckling tracheal cilia movement. Results: The study showed that Xining cough syrup can promote glandular secretion and mucus movement and tracheal ciliary movement in ducklings, and can significantly increase the amount of sputum discharged from rats. In addition, it can significantly prolong the cough latency and reduce the number of coughs in guinea pigs and mice. Conclusion: Xining cough syrup has good antitussive effect