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目的探讨半乳糖凝集素-3(Galectin-3)和CDX-2在胃癌患者中的表达及其意义。方法收集胃癌组织90例及正常胃粘膜组织40例,采用免疫组织化学SP法检测组织中Galectin-3和CDX-2的表达。结果 Galectin-3和CDX-2在胃癌组织中均有表达,阳性表达率分别为84.4%和77.8.%;CDX-2在正常组织中不表达,Galectin-3在正常组织中的阳性表达率为10.0%;Galectin-3和CDX-2的表达成正相关(r=0.486);Galectin-3和CDX-2与胃癌的预后有关。结论 Galectin-3和CDX-2对于判断胃癌的浸润、恶性程度及患者的预后具有重要的临床价值。
Objective To investigate the expression and significance of Galectin-3 and CDX-2 in gastric cancer. Methods 90 cases of gastric cancer and 40 cases of normal gastric mucosa were collected. The expression of Galectin-3 and CDX-2 were detected by immunohistochemical SP method. Results The expressions of Galectin-3 and CDX-2 in gastric cancer tissues were 84.4% and 77.8%, respectively. The expressions of Galectin-3 and CDX-2 in normal tissues were 10.0%. There was a positive correlation between Galectin-3 and CDX-2 expression (r = 0.486). Galectin-3 and CDX-2 were correlated with the prognosis of gastric cancer. Conclusions Galectin-3 and CDX-2 have important clinical value in judging the infiltration, malignancy and prognosis of gastric cancer.