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研究羟基喜树碱体外诱人胰腺癌细胞株SW－1990凋亡的作用。方法：以不同浓度的羟基喜树碱处理在体外培养的胰腺细胞，以电子显微镜、流式细胞仪和原位末端标记分析和检测细胞凋亡。结果：在0．05mg/ml浓度下，羟基喜树碱作用于体外培养的胰腺癌细胞20小时后，肿瘤细胞的凋亡率在13．2％－15．3％之间，主要以早、中期的表现为主：在0．lmg／ml浓度下，作用20小时后，凋亡率在26．l％－30．4％之间，凋亡形态学表现主要以晚期为主。结论：羟基喜树碱可作为细胞凋亡诱导剂用于胰腺癌治疗。
To study the effect of hydroxycamptothecin on pancreatic cancer cell line SW-1990 in vitro. Methods: Pancreatic cells cultured in vitro were treated with different concentrations of hydroxycamptothecin. Cell apoptosis was analyzed by electron microscopy, flow cytometry and in situ terminal labeling. Results: Under the concentration of 0.05mg / ml, the apoptosis rate of tumor cells after treated with hydroxycamptothecin for 12 hours in vitro was between 13.2% -15.3% Medium-term performance-based: at 0. lmg / ml concentration, the role of 20 hours after the apoptosis rate of 26. l% -30.4%, the morphological features of apoptosis mainly in the late. Conclusion: HCPT can be used as an apoptosis inducer in the treatment of pancreatic cancer.