复方甲地孕酮微囊注射液为本校制药厂研制的一种缓慢释放长效避孕注射剂。避孕有效率达99.1%,对其安全性曾作过一些临床研究,未发现有害效应。为探索该药是否改变细胞的诱变环境和遗传影响,作者对使用此注射剂的65例妇女,进行了外周血淋巴细胞染色体畸变率、姊妹染色单体互换率(sister chromatid exchanges,SCE)和银染核仁形成 Compound megestrol microcapsule injection for the school’s pharmaceutical factory developed a slow release long-acting contraceptive injection. Contraceptive efficiency of 99.1%, made some clinical studies on its safety, no harmful effects were found. To explore whether the drug can alter the mutagenic environment and genetic effects of the cells, the authors conducted a survey of 65 chil- dren with this injection using chromosomal aberrations in peripheral blood lymphocytes, sister chromatid exchanges (SCE) and Silver stained nucleolus formation