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目的探讨自身免疫性肝炎(autoimmune hepatitis,AIH)患者外周血中髓系来源抑制性细胞(myeloid-derivedsup-pressorcells,MDSCs)频率及其与疾病的关系。方法采集22例AIH患者和24例健康对照者外周血,用流式细胞仪分析MDSCs频率,对患者MDSCs频率与肝脏生化指标进行相关性分析。结果非肝硬化组外周血MDSCs频率明显高于肝硬化组和健康对照组,差异有统计学意义(P<0.05)。肝硬化组与健康对照组相比,差异无统计学意义(P>0.05)。所有患者MDSCs频率与ALT和AST水平成正相关。结论在AIH非肝硬化期,外周血MDSCs频率呈反馈性增高,抑制体内自身免疫反应;在AIH肝硬化期,各种原因致使MDSCs数量下调,加速肝细胞损伤和肝硬化进程。
Objective To investigate the frequency of myeloid-derived superoxide dismutase (MDSCs) in peripheral blood of patients with autoimmune hepatitis (AIH) and its relationship with disease. Methods Peripheral blood samples of 22 patients with AIH and 24 healthy controls were collected. The frequency of MDSCs was analyzed by flow cytometry. The correlation between the frequency of MDSCs and the biochemical indexes of liver was analyzed. Results The frequency of MDSCs in non-cirrhotic group was significantly higher than that in cirrhosis and healthy controls (P <0.05). There was no significant difference between the cirrhosis group and the healthy control group (P> 0.05). The frequency of MDSCs in all patients was positively correlated with ALT and AST levels. Conclusions In non-cirrhotic AIH, the frequency of MDSCs in peripheral blood is increased retrospectively and inhibits the autoimmune reaction in vivo. In the period of AIH cirrhosis, the number of MDSCs is down-regulated due to various reasons, accelerating the process of liver cell injury and liver cirrhosis.